Kava and Warfarin

Supplement–drug interaction evidence from the TruthStack database.

SeverityHIGH
Evidence TierModerate
Interaction TypeSAFETY CONCERN
MechanismMETABOLISM
Last Reviewed2026-02-24
Source Verification
Attestation METHODOLOGY_ATTESTED
Corpus manifest 26b2d684...
Last reviewed 2026-02-24
Primary source 12495559
Live attestation Query API — returns signed DAA ID per request
Data license CC BY 4.0

Summary

Kava has documented hepatotoxic potential and inhibits multiple CYP enzymes. May unpredictably alter warfarin metabolism.

Higher-Concern Contexts

This interaction may be of particular concern in the following contexts:

API Reference

GET https://api.truthstack.co/v1/check?c1=Kava&c2=Warfarin

Open, unauthenticated. Returns JSON. Developer documentation

Sources

Primary: 12495559

Related Interactions

Cbd + Warfarin Goldenseal + Warfarin Alprazolam + Kava Clonazepam + Kava Hydrocodone + Kava Kava + Lorazepam Kava + Methotrexate Kava + Oxycodone
What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.