Kava and Methotrexate
Supplement–drug interaction evidence from the TruthStack database.
| Severity | CRITICAL |
|---|---|
| Evidence Tier | Moderate |
| Interaction Type | CONTRAINDICATED |
| Mechanism | HEPATIC |
| Last Reviewed | 2026-02-15 |
Summary
Both kava and methotrexate are hepatotoxic. Combined use dramatically increases risk of liver failure. This is a high-risk combination. Discuss with your prescriber or pharmacist before combining.
Higher-Concern Contexts
This interaction may be of particular concern in the following contexts:
- hepatic impairment
API Reference
GET https://api.truthstack.co/v1/check?c1=kava&c2=methotrexate
Open, unauthenticated. Returns JSON. Developer documentation
Related Interactions
What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.