Goldenseal and Simvastatin

Supplement–drug interaction evidence from the TruthStack database.

SeverityHIGH
Evidence TierModerate
Interaction TypePHARMACODYNAMIC RISK
MechanismPHARMACOKINETIC
Last Reviewed2026-02-15

Summary

Goldenseal CYP3A4 inhibition increases simvastatin levels. Rhabdomyolysis risk. Combination is flagged in literature or use non-CYP3A4 statin. Discuss with your prescriber or pharmacist.

API Reference

GET https://api.truthstack.co/v1/check?c1=goldenseal&c2=simvastatin

Open, unauthenticated. Returns JSON. Developer documentation

Related Interactions

Bergamot + Simvastatin Cyclosporine + Goldenseal Goldenseal + Tacrolimus Goldenseal + Warfarin Grapefruit Extract + Simvastatin Red Yeast Rice + Simvastatin Biotin + Simvastatin Calcium + Simvastatin
What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.