Cyclosporine and Goldenseal
Supplement–drug interaction evidence from the TruthStack database.
| Severity | CRITICAL |
|---|---|
| Evidence Tier | Moderate |
| Interaction Type | CONTRAINDICATED |
| Mechanism | PHARMACOKINETIC |
| Last Reviewed | 2026-02-15 |
Summary
Goldenseal CYP3A4 inhibition increases cyclosporine levels. This is a high-risk combination. Discuss with your prescriber or pharmacist before combining.
API Reference
GET https://api.truthstack.co/v1/check?c1=cyclosporine&c2=goldenseal
Open, unauthenticated. Returns JSON. Developer documentation
Related Interactions
What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.