Bergamot and Simvastatin

Supplement–drug interaction evidence from the TruthStack database.

SeverityCRITICAL
Evidence TierModerate
Interaction TypeCONTRAINDICATED
MechanismPHARMACOKINETIC
Last Reviewed2026-02-15

Summary

Bergamot contains bergamottin, a furanocoumarin CYP3A4 inhibitor similar to grapefruit. Simvastatin highly CYP3A4-dependent. Rhabdomyolysis risk. This is a high-risk combination. Discuss with your prescriber or pharmacist before combining.

API Reference

GET https://api.truthstack.co/v1/check?c1=bergamot&c2=simvastatin

Open, unauthenticated. Returns JSON. Developer documentation

Related Interactions

Bergamot + Cyclosporine Bergamot + Tacrolimus Grapefruit Extract + Simvastatin Red Yeast Rice + Simvastatin Atorvastatin + Bergamot Biotin + Simvastatin Calcium + Simvastatin Cbd + Simvastatin
What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.