Cyclosporine and Red Yeast Rice

Supplement–drug interaction evidence from the TruthStack database.

SeverityCRITICAL
Evidence TierModerate
Interaction TypeCONTRAINDICATED
MechanismPHARMACOKINETIC
Last Reviewed2026-02-15

Summary

This is a high-risk combination. Discuss with your prescriber or pharmacist before combining. Cyclosporine inhibits CYP3A4 and OATP1B1, dramatically increasing monacolin K levels. Extreme rhabdomyolysis risk.

API Reference

GET https://api.truthstack.co/v1/check?c1=cyclosporine&c2=red%20yeast%20rice

Open, unauthenticated. Returns JSON. Developer documentation

Related Interactions

Bergamot + Cyclosporine Cbd + Cyclosporine Cyclosporine + Echinacea Cyclosporine + Goldenseal Cyclosporine + Grapefruit Extract Cyclosporine + Piperine Cyclosporine + Quercetin Atorvastatin + Red Yeast Rice
What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.