Methotrexate and St Johns Wort

Supplement–drug interaction evidence from the TruthStack database.

SeverityHIGH
Evidence TierModerate
Interaction TypePHARMACODYNAMIC RISK
MechanismPHARMACOKINETIC
Last Reviewed2026-02-15

Summary

St. Johns Wort induces multiple CYP enzymes and P-gp, potentially reducing methotrexate levels. Risk of treatment failure in cancer/autoimmune therapy. Discuss with your prescriber or pharmacist.

API Reference

GET https://api.truthstack.co/v1/check?c1=methotrexate&c2=st%20johns%20wort

Open, unauthenticated. Returns JSON. Developer documentation

Related Interactions

Kava + Methotrexate Methylene Blue + St. John'S Wort Clozapine + St Johns Wort Ethinyl Estradiol + St Johns Wort Phenytoin + St Johns Wort St Johns Wort + Theophylline Amitriptyline + St Johns Wort Citalopram + St Johns Wort
What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.