Methylene Blue and St. John'S Wort

Supplement–drug interaction evidence from the TruthStack database.

SeverityCRITICAL
Evidence TierModerate
Interaction TypeSAFETY CONCERN
MechanismPHARMACODYNAMIC
Last Reviewed2026-02-15
Source Verification
Attestation METHODOLOGY_ATTESTED
Corpus manifest 26b2d684...
Last reviewed 2026-02-15
Live attestation Query API — returns signed DAA ID per request
Data license CC BY 4.0

Summary

Published pharmacology reference. Discuss with your provider.

API Reference

GET https://api.truthstack.co/v1/check?c1=Methylene%20Blue&c2=St.%20John's%20Wort

Open, unauthenticated. Returns JSON. Developer documentation

Related Interactions

5-HTP + Methylene Blue Methylene Blue + SAM-E Methylene Blue + Tryptophan Clozapine + St Johns Wort Ethinyl Estradiol + St Johns Wort Phenytoin + St Johns Wort St Johns Wort + Theophylline Amitriptyline + St Johns Wort
What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.