Melatonin and Sertraline
Supplement–drug interaction evidence from the TruthStack database.
| Severity | HIGH |
|---|---|
| Evidence Tier | Moderate |
| Interaction Type | SEROTONERGIC RISK |
| Mechanism | PHARMACODYNAMIC |
| Last Reviewed | 2026-02-24 |
Source Verification
Attestation METHODOLOGY_ATTESTED
Corpus manifest 26b2d684...
Last reviewed 2026-02-24
Primary source 25503107
Live attestation Query API — returns signed DAA ID per request
Data license CC BY 4.0
Summary
Melatonin is metabolized by CYP1A2 and has serotonergic properties. SSRIs may inhibit CYP1A2, increasing melatonin levels. Additive serotonergic effects theoretically possible. FAERS: 2,390 reports. Generally lower risk than other serotonergic combinations but monitor for excessive sedation.
API Reference
GET https://api.truthstack.co/v1/check?c1=melatonin&c2=sertraline
Open, unauthenticated. Returns JSON. Developer documentation
Sources
Primary: 25503107
Related Interactions
What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.