Cbd and Sertraline
Supplement–drug interaction evidence from the TruthStack database.
| Severity | HIGH |
|---|---|
| Evidence Tier | Moderate |
| Interaction Type | SAFETY CONCERN |
| Mechanism | PHARMACOKINETIC |
| Last Reviewed | 2026-02-15 |
Summary
CBD inhibits CYP2C19 (sertraline metabolism). Increased sertraline levels and possible serotonin excess. Monitor for agitation, tremor, diarrhea. Inform prescriber about CBD use.
API Reference
GET https://api.truthstack.co/v1/check?c1=cbd&c2=sertraline
Open, unauthenticated. Returns JSON. Developer documentation
Related Interactions
What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.