Sertraline and St Johns Wort
Supplement–drug interaction evidence from the TruthStack database.
| Severity | CRITICAL |
|---|---|
| Evidence Tier | Moderate |
| Interaction Type | SAFETY CONCERN |
| Mechanism | PHARMACODYNAMIC |
| Last Reviewed | 2026-02-24 |
Source Verification
Attestation METHODOLOGY_ATTESTED
Corpus manifest 26b2d684...
Last reviewed 2026-02-24
Primary source 11769272
Live attestation Query API — returns signed DAA ID per request
Data license CC BY 4.0
Summary
St. John's Wort inhibits serotonin reuptake (hypericin, hyperforin) similarly to SSRIs. Combined use creates dual serotonin reuptake inhibition, documented to cause serotonin syndrome. Multiple case reports. Widely contraindicated. FAERS: 27 adverse events.
API Reference
GET https://api.truthstack.co/v1/check?c1=sertraline&c2=st_johns_wort
Open, unauthenticated. Returns JSON. Developer documentation
Sources
Primary: 11769272
Related Interactions
What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.