Green Tea Extract and Methotrexate

Supplement–drug interaction evidence from the TruthStack database.

SeverityHIGH
Evidence TierModerate
Interaction TypePHARMACODYNAMIC RISK
MechanismHEPATIC
Last Reviewed2026-02-15

Summary

Both green tea extract (high-dose EGCG) and methotrexate carry hepatotoxicity risk. Additive liver injury potential. Discuss with your prescriber or pharmacist.

Higher-Concern Contexts

This interaction may be of particular concern in the following contexts:

API Reference

GET https://api.truthstack.co/v1/check?c1=green%20tea%20extract&c2=methotrexate

Open, unauthenticated. Returns JSON. Developer documentation

Related Interactions

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What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.