Folate and Zinc

Supplement–drug interaction evidence from the TruthStack database.

SeverityMODERATE
Evidence TierModerate
Interaction TypePHARMACODYNAMIC RISK
Mechanismpharmacokinetic
Last Reviewed2026-02-07

Summary

Ensure adequate zinc when taking high-dose folate (pregnancy) Discuss with your prescriber or pharmacist.

Higher-Concern Contexts

This interaction may be of particular concern in the following contexts:

API Reference

GET https://api.truthstack.co/v1/check?c1=folate&c2=zinc

Open, unauthenticated. Returns JSON. Developer documentation

Related Interactions

Cobalamin B12 + Folate B9 Folate B9 + SAMe SAM-E + Vitamin B9 Vitamin B12 + Vitamin B9 Copper + Zinc Amlodipine + Folate Atorvastatin + Folate Citalopram + Folate
What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.