Copper and Zinc

Supplement–drug interaction evidence from the TruthStack database.

SeverityCRITICAL
Evidence TierModerate
Interaction TypeSAFETY CONCERN
MechanismPHARMACOKINETIC
Last Reviewed2026-02-24
Source Verification
Attestation METHODOLOGY_ATTESTED
Corpus manifest 26b2d684...
Last reviewed 2026-02-24
Primary source 2407098
Live attestation Query API — returns signed DAA ID per request
Data license CC BY 4.0

Summary

Zinc and copper compete for absorption via metallothionein binding. Chronic zinc (>40mg/day) depletes copper stores, potentially causing copper deficiency anemia, neutropenia, and irreversible neurological damage. Well-established. If supplementing zinc long-term, add copper at ~1mg per 15mg zinc ratio.

API Reference

GET https://api.truthstack.co/v1/check?c1=Copper&c2=Zinc

Open, unauthenticated. Returns JSON. Developer documentation

Sources

Primary: 2407098

Related Interactions

Copper + Disulfiram Copper + Molybdenum Amlodipine + Zinc Atorvastatin + Zinc Citalopram + Zinc Cyclosporine + Zinc Duloxetine + Zinc Escitalopram + Zinc
What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.