Cobalamin B12 and Folate B9
Supplement–drug interaction evidence from the TruthStack database.
| Severity | CRITICAL |
|---|---|
| Evidence Tier | Moderate |
| Interaction Type | SYNERGISTIC CRITICAL |
| Last Reviewed | 2026-02-07 |
Summary
ALWAYS supplement together; assess B12 before high-dose folate. WARNING: High-dose folate without B12 can mask deficiency anemia while neuro damage progresses
API Reference
GET https://api.truthstack.co/v1/check?c1=cobalamin_b12&c2=folate_b9
Open, unauthenticated. Returns JSON. Developer documentation
Related Interactions
What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.