CQR-300 and Sertraline
Supplement–drug interaction evidence from the TruthStack database.
| Severity | MODERATE |
|---|---|
| Evidence Tier | Moderate |
| Interaction Type | PHARMACODYNAMIC RISK |
| Mechanism | SEROTONERGIC |
| Last Reviewed | 2026-03-03 |
Source Verification
Attestation METHODOLOGY_ATTESTED
Corpus manifest 26b2d684...
Last reviewed 2026-03-03
Live attestation Query API — returns signed DAA ID per request
Data license CC BY 4.0
Summary
CQR-300 increased plasma serotonin by 115% in an 8-week trial (Kuate 2015, n=61). Sertraline inhibits serotonin reuptake. Combining may produce additive serotonergic effects. While serotonin syndrome from this combination has not been reported, the magnitude of CQR-300's serotonin elevation warrants caution. Discuss with prescriber before combining.
API Reference
GET https://api.truthstack.co/v1/check?c1=CQR-300&c2=Sertraline
Open, unauthenticated. Returns JSON. Developer documentation
Related Interactions
What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.