Cbd and Simvastatin
Supplement–drug interaction evidence from the TruthStack database.
| Severity | HIGH |
|---|---|
| Evidence Tier | Moderate |
| Interaction Type | BLEEDING RISK |
| Mechanism | PHARMACOKINETIC |
| Last Reviewed | 2026-02-15 |
Summary
CBD inhibits CYP3A4. Simvastatin is highly CYP3A4-dependent. Significant statin level increase possible. Myopathy and rhabdomyolysis risk. Combination is flagged in literature or switch to rosuvastatin/pravastatin.
API Reference
GET https://api.truthstack.co/v1/check?c1=cbd&c2=simvastatin
Open, unauthenticated. Returns JSON. Developer documentation
Related Interactions
What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.