Bitter Melon and Metformin

Supplement–drug interaction evidence from the TruthStack database.

SeverityMODERATE
Evidence TierModerate
Interaction TypePHARMACODYNAMIC RISK
MechanismPHARMACODYNAMIC
Last Reviewed2026-02-15

Summary

Bitter melon has insulin-mimetic properties. Additive glucose lowering with metformin. Discuss with your prescriber or pharmacist.

Higher-Concern Contexts

This interaction may be of particular concern in the following contexts:

API Reference

GET https://api.truthstack.co/v1/check?c1=bitter%20melon&c2=metformin

Open, unauthenticated. Returns JSON. Developer documentation

Related Interactions

Biotin + Metformin Bitter Melon + Glipizide Bitter Melon + Insulin Glargine Bitter Melon + Insulin Lispro Black Cohosh + Metformin Calcium + Metformin CoQ10 + Metformin Echinacea + Metformin
What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.