Berberine and Metformin
Supplement–drug interaction evidence from the TruthStack database.
| Severity | HIGH |
|---|---|
| Evidence Tier | Moderate |
| Interaction Type | PHARMACODYNAMIC RISK |
| Mechanism | PHARMACODYNAMIC |
| Last Reviewed | 2026-02-24 |
Source Verification
Attestation METHODOLOGY_ATTESTED
Corpus manifest 26b2d684...
Last reviewed 2026-02-24
Primary source 32268543
Live attestation Query API — returns signed DAA ID per request
Data license CC BY 4.0
Summary
Both berberine and metformin lower blood glucose via overlapping mechanisms (AMPK activation). Combined use significantly increases hypoglycemia risk. Berberine also inhibits CYP3A4/CYP2D6. Monitor blood glucose closely and discuss with prescriber.
API Reference
GET https://api.truthstack.co/v1/check?c1=Berberine&c2=Metformin
Open, unauthenticated. Returns JSON. Developer documentation
Sources
Primary: 32268543
Related Interactions
What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.