Bitter Melon and Insulin Lispro

Supplement–drug interaction evidence from the TruthStack database.

SeverityHIGH
Evidence TierModerate
Interaction TypePHARMACODYNAMIC RISK
MechanismPHARMACODYNAMIC
Last Reviewed2026-02-15
Source Verification
Attestation METHODOLOGY_ATTESTED
Corpus manifest 26b2d684...
Last reviewed 2026-02-15
Live attestation Query API — returns signed DAA ID per request
Data license CC BY 4.0

Summary

Bitter melon insulin-mimetic effects plus rapid-acting insulin increases hypoglycemia risk. Discuss with your prescriber or pharmacist.

Higher-Concern Contexts

This interaction may be of particular concern in the following contexts:

API Reference

GET https://api.truthstack.co/v1/check?c1=bitter%20melon&c2=insulin%20lispro

Open, unauthenticated. Returns JSON. Developer documentation

Related Interactions

Bitter Melon + Glipizide Bitter Melon + Insulin Glargine Ginseng + Insulin Lispro Bitter Melon + Semaglutide Bitter Melon + Tirzepatide Bitter Melon + Metformin Cinnamon + Insulin Lispro
What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.