SSRIs and St Johns Wort

Supplement–drug interaction evidence from the TruthStack database.

SeverityCRITICAL
Evidence TierModerate
Interaction TypeSEROTONERGIC RISK
MechanismSEROTONERGIC
Last Reviewed2026-02-16

Summary

St Johns Wort has serotonin reuptake inhibition activity. Combined with SSRIs, published case series describe serotonin syndrome. This combination is widely flagged as contraindicated. Discuss with your prescriber or pharmacist before combining.

API Reference

GET https://api.truthstack.co/v1/check?c1=SSRIs&c2=St%20Johns%20Wort

Open, unauthenticated. Returns JSON. Developer documentation

Related Interactions

Methylene Blue + St. John'S Wort Clozapine + St Johns Wort Ethinyl Estradiol + St Johns Wort Phenytoin + St Johns Wort St Johns Wort + Theophylline Amitriptyline + St Johns Wort Citalopram + St Johns Wort Escitalopram + St Johns Wort
What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.