Oral Contraceptives and St Johns Wort

Supplement–drug interaction evidence from the TruthStack database.

SeverityCRITICAL
Evidence TierModerate
Interaction TypeCONTRAINDICATED
MechanismMETABOLISM
Last Reviewed2026-02-16

Summary

St Johns Wort induces CYP3A4, reducing oral contraceptive hormone levels. Literature documents contraceptive failure and unintended pregnancy. This combination is widely contraindicated. Clinician review essential.

Higher-Concern Contexts

This interaction may be of particular concern in the following contexts:

API Reference

GET https://api.truthstack.co/v1/check?c1=Oral%20Contraceptives&c2=St%20Johns%20Wort

Open, unauthenticated. Returns JSON. Developer documentation

Related Interactions

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What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.