Lorazepam and St Johns Wort

Supplement–drug interaction evidence from the TruthStack database.

SeverityLOW
Evidence TierLimited
Interaction TypeSAFETY CONCERN
MechanismPHARMACOKINETIC
Last Reviewed2026-02-15

Summary

Lorazepam is primarily glucuronidated, not CYP-metabolized. Interaction risk lower than other benzodiazepines, but SJW may still affect glucuronidation. Monitor. Discuss with your prescriber or pharmacist.

What We Don't Know

This interaction has limited evidence. Key gaps may include: direct clinical trial data for this specific combination, dose-response relationships, and long-term outcome data. Absence of evidence is not evidence of absence.

API Reference

GET https://api.truthstack.co/v1/check?c1=lorazepam&c2=st_johns_wort

Open, unauthenticated. Returns JSON. Developer documentation

Related Interactions

Kava + Lorazepam Methylene Blue + St. John'S Wort Clozapine + St Johns Wort Ethinyl Estradiol + St Johns Wort Phenytoin + St Johns Wort St Johns Wort + Theophylline Amitriptyline + St Johns Wort Citalopram + St Johns Wort
What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.