Licorice Root and Spironolactone

Supplement–drug interaction evidence from the TruthStack database.

SeverityHIGH
Evidence TierModerate
Interaction TypeANTAGONISTIC
MechanismPHARMACODYNAMIC
Last Reviewed2026-02-15

Summary

Licorice has pseudo-hyperaldosteronism effects that directly antagonize spironolactone mechanism. This is a high-risk combination. Discuss with your prescriber or pharmacist before combining as licorice undermines spironolactone therapy.

API Reference

GET https://api.truthstack.co/v1/check?c1=licorice%20root&c2=spironolactone

Open, unauthenticated. Returns JSON. Developer documentation

Related Interactions

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What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.