Hydrochlorothiazide and Licorice Root

Supplement–drug interaction evidence from the TruthStack database.

SeverityHIGH
Evidence TierModerate
Interaction TypePHARMACODYNAMIC RISK
MechanismPHARMACODYNAMIC
Last Reviewed2026-02-15

Summary

Licorice causes potassium loss via pseudo-hyperaldosteronism. Combined with thiazide diuretics equals severe hypokalemia with cardiac arrhythmia risk. Monitor potassium. Discuss with your prescriber or pharmacist.

API Reference

GET https://api.truthstack.co/v1/check?c1=hydrochlorothiazide&c2=licorice%20root

Open, unauthenticated. Returns JSON. Developer documentation

Related Interactions

Amiodarone + Licorice Root Digoxin + Licorice Root Licorice Root + Sotalol Amlodipine + Licorice Licorice + Omeprazole Furosemide + Licorice Root Licorice Root + Spironolactone Atorvastatin + Licorice
What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.