Kava and Tramadol

Supplement–drug interaction evidence from the TruthStack database.

SeverityHIGH
Evidence TierModerate
Interaction TypePHARMACODYNAMIC RISK
MechanismPHARMACODYNAMIC
Last Reviewed2026-02-15
Source Verification
Attestation METHODOLOGY_ATTESTED
Corpus manifest 26b2d684...
Last reviewed 2026-02-15
Live attestation Query API — returns signed DAA ID per request
Data license CC BY 4.0

Summary

Kava adds CNS depression to tramadol. Also potential hepatotoxic stacking. Combination is flagged in literature. Discuss with your prescriber or pharmacist.

API Reference

GET https://api.truthstack.co/v1/check?c1=kava&c2=tramadol

Open, unauthenticated. Returns JSON. Developer documentation

Related Interactions

Alprazolam + Kava Clonazepam + Kava Hydrocodone + Kava Kava + Lorazepam Kava + Methotrexate Kava + Oxycodone Benzodiazepines + Kava Diazepam + Kava
What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.