Hydrochlorothiazide and Vitamin D

Supplement–drug interaction evidence from the TruthStack database.

SeverityMODERATE
Evidence TierModerate
Interaction TypePHARMACODYNAMIC RISK
MechanismPHARMACODYNAMIC
Last Reviewed2026-02-15

Summary

Thiazide diuretics reduce calcium excretion. High-dose vitamin D increases calcium absorption. Combination may cause hypercalcemia. Monitor calcium levels. Discuss with your prescriber or pharmacist.

API Reference

GET https://api.truthstack.co/v1/check?c1=hydrochlorothiazide&c2=vitamin_d

Open, unauthenticated. Returns JSON. Developer documentation

Related Interactions

Calcium + Vitamin D Hydrochlorothiazide + Licorice Root Magnesium + Vitamin D Amlodipine + Vitamin D Atorvastatin + Vitamin D Citalopram + Vitamin D Cyclosporine + Vitamin D Duloxetine + Vitamin D
What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.