Donepezil and Melatonin

Supplement–drug interaction evidence from the TruthStack database.

SeverityMODERATE
Evidence TierModerate
Interaction TypePHARMACODYNAMIC RISK
MechanismPHARMACODYNAMIC
Last Reviewed2026-02-15

Summary

Melatonin may increase sedation and fall risk when combined with donepezil, especially in elderly patients. Discuss with your prescriber or pharmacist.

Higher-Concern Contexts

This interaction may be of particular concern in the following contexts:

API Reference

GET https://api.truthstack.co/v1/check?c1=donepezil&c2=melatonin

Open, unauthenticated. Returns JSON. Developer documentation

Related Interactions

Donepezil + Kava Amlodipine + Melatonin Atorvastatin + Melatonin Citalopram + Melatonin Cyclosporine + Melatonin Duloxetine + Melatonin Escitalopram + Melatonin Fluoxetine + Melatonin
What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.