Donepezil and Kava
Supplement–drug interaction evidence from the TruthStack database.
| Severity | HIGH |
|---|---|
| Evidence Tier | Moderate |
| Interaction Type | PHARMACODYNAMIC RISK |
| Mechanism | PHARMACODYNAMIC |
| Last Reviewed | 2026-02-15 |
Summary
Kava sedation opposes the cognitive benefits of donepezil and increases fall/delirium risk in elderly patients. Combination is flagged in literature. Discuss with your prescriber or pharmacist.
Higher-Concern Contexts
This interaction may be of particular concern in the following contexts:
- elderly
API Reference
GET https://api.truthstack.co/v1/check?c1=donepezil&c2=kava
Open, unauthenticated. Returns JSON. Developer documentation
Related Interactions
What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.