Creatine and Omeprazole

Supplement–drug interaction evidence from the TruthStack database.

SeverityMODERATE
Evidence TierModerate
Interaction TypeSAFETY CONCERN
MechanismPHARMACOKINETIC
Last Reviewed2026-02-16

Summary

Chronic PPI use associated with reduced creatinine clearance and increased acute kidney injury risk. Combined with creatine supplementation, kidney function monitoring may be informative, especially in adults over 50.

Higher-Concern Contexts

This interaction may be of particular concern in the following contexts:

API Reference

GET https://api.truthstack.co/v1/check?c1=Creatine&c2=Omeprazole

Open, unauthenticated. Returns JSON. Developer documentation

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What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.