Cobalamin B12 and SAMe

Supplement–drug interaction evidence from the TruthStack database.

SeverityCRITICAL
Evidence TierModerate
Interaction TypeSYNERGISTIC CRITICAL
Mechanismphysiological
Last Reviewed2026-02-07

Summary

NEVER use SAM-e without B12 supplementation Discuss with your prescriber or pharmacist.

API Reference

GET https://api.truthstack.co/v1/check?c1=cobalamin_b12&c2=same

Open, unauthenticated. Returns JSON. Developer documentation

Related Interactions

Cobalamin B12 + Folate B9 Folate B9 + SAMe Methylene Blue + SAM-E 5-HTP + SAM-E SAM-E + Vitamin B12 SAM-E + Vitamin B9 Vitamin B12 + Vitamin B9 5 Htp + SAMe
What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.