Ashwagandha and Levothyroxine
Supplement–drug interaction evidence from the TruthStack database.
| Severity | MODERATE |
|---|---|
| Evidence Tier | Moderate |
| Interaction Type | ANTAGONISTIC |
| Mechanism | PHARMACODYNAMIC |
| Last Reviewed | 2026-02-24 |
Source Verification
Attestation METHODOLOGY_ATTESTED
Corpus manifest 26b2d684...
Last reviewed 2026-02-24
Primary source 28829155
Live attestation Query API — returns signed DAA ID per request
Data license CC BY 4.0
Summary
Ashwagandha has demonstrated thyroid-stimulating activity — increasing serum T3 and T4 in subclinical hypothyroidism trials. In patients on levothyroxine, ashwagandha may alter thyroid hormone levels and require dose adjustment. FAERS: 36 reports. Monitor thyroid panel.
API Reference
GET https://api.truthstack.co/v1/check?c1=ashwagandha&c2=levothyroxine
Open, unauthenticated. Returns JSON. Developer documentation
Sources
Primary: 28829155
Related Interactions
What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.