Levothyroxine and Semaglutide

Supplement–drug interaction evidence from the TruthStack database.

SeverityCRITICAL
Evidence TierModerate
Interaction TypeABSORPTION INTERFERENCE
MechanismABSORPTION
Last Reviewed2026-02-16

Summary

GLP-1 receptor agonists delay gastric emptying, potentially altering levothyroxine absorption timing. Levothyroxine has a narrow therapeutic index and is timing-sensitive. Literature flags altered thyroid hormone levels when co-administered. Discuss dosing schedule with your prescriber or pharmacist.

API Reference

GET https://api.truthstack.co/v1/check?c1=Levothyroxine&c2=Semaglutide

Open, unauthenticated. Returns JSON. Developer documentation

Related Interactions

Levothyroxine + Tirzepatide Biotin + Levothyroxine Black Cohosh + Levothyroxine Calcium + Levothyroxine Calcium + Semaglutide Cbd + Levothyroxine CoQ10 + Levothyroxine Echinacea + Levothyroxine
What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.