Amphetamine and St Johns Wort

Supplement–drug interaction evidence from the TruthStack database.

SeverityHIGH
Evidence TierModerate
Interaction TypeSEROTONERGIC RISK
MechanismPHARMACODYNAMIC
Last Reviewed2026-02-15

Summary

St. John's Wort combined with amphetamine increases serotonin syndrome risk. Both agents increase synaptic serotonin. Additionally, SJW induces CYP3A4 which may alter amphetamine metabolism. Combination is flagged in literature or monitor closely with prescriber.

API Reference

GET https://api.truthstack.co/v1/check?c1=amphetamine&c2=st_johns_wort

Open, unauthenticated. Returns JSON. Developer documentation

Related Interactions

Methylene Blue + St. John'S Wort Clozapine + St Johns Wort Ethinyl Estradiol + St Johns Wort Phenytoin + St Johns Wort St Johns Wort + Theophylline Amitriptyline + St Johns Wort Citalopram + St Johns Wort Escitalopram + St Johns Wort
What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.