Alpha-GPC and Piracetam
Supplement–drug interaction evidence from the TruthStack database.
| Severity | MODERATE |
|---|---|
| Evidence Tier | Moderate |
| Interaction Type | SYNERGISTIC |
| Mechanism | PHARMACODYNAMIC |
| Last Reviewed | 2026-02-15 |
Summary
Racetams increase ACh utilization; without choline source causes depletion headache. Always pair racetams with Alpha-GPC or CDP-Choline
API Reference
GET https://api.truthstack.co/v1/check?c1=Alpha-GPC&c2=Piracetam
Open, unauthenticated. Returns JSON. Developer documentation
Related Interactions
What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.