Alpha-GPC and Phosphatidylcholine
Supplement–drug interaction evidence from the TruthStack database.
| Severity | MODERATE |
|---|---|
| Evidence Tier | Moderate |
| Interaction Type | NEUTRAL |
| Mechanism | PHARMACODYNAMIC |
| Last Reviewed | 2026-02-16 |
Summary
Both are choline donors. Combined use increases total choline intake, which gut bacteria convert to TMAO. Emerging evidence links elevated TMAO to cardiovascular risk in some populations, though causality is debated. Review total choline intake with clinician.
API Reference
GET https://api.truthstack.co/v1/check?c1=Alpha-GPC&c2=Phosphatidylcholine
Open, unauthenticated. Returns JSON. Developer documentation
Related Interactions
What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.