5 Htp and Amphetamine

Supplement–drug interaction evidence from the TruthStack database.

SeverityMODERATE
Evidence TierModerate
Interaction TypeSEROTONERGIC RISK
MechanismPHARMACODYNAMIC
Last Reviewed2026-02-15

Summary

5-HTP increases serotonin. Amphetamines increase monoamine release including serotonin. Combining may increase serotonin syndrome risk and cardiovascular effects. Discuss with your prescriber or pharmacist.

API Reference

GET https://api.truthstack.co/v1/check?c1=5_htp&c2=amphetamine

Open, unauthenticated. Returns JSON. Developer documentation

Related Interactions

5-HTP + Methylene Blue 5-HTP + SAM-E 5 Htp + Amitriptyline 5 Htp + SAMe 5 Htp + St Johns Wort 5 Htp + Tramadol 5 Htp + Trazodone 5-HTP + Rhodiola
What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.