5-HTP and Rhodiola

Supplement–drug interaction evidence from the TruthStack database.

SeverityHIGH
Evidence TierModerate
Interaction TypeSAFETY CONCERN
MechanismPHARMACODYNAMIC
Last Reviewed2026-02-15

Summary

Rhodiola is mild MAO inhibitor; amplifies serotonin accumulation exponentially with 5-HTP. Do not combine; serotonin syndrome risk

API Reference

GET https://api.truthstack.co/v1/check?c1=5-HTP&c2=Rhodiola

Open, unauthenticated. Returns JSON. Developer documentation

Related Interactions

5-HTP + Methylene Blue 5-HTP + SAM-E 5 Htp + Amitriptyline 5 Htp + SAMe 5 Htp + St Johns Wort 5 Htp + Tramadol 5 Htp + Trazodone 5-HTP + Tryptophan
What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.