Sulforaphane and Vitamin D
Supplement–drug interaction evidence from the TruthStack database.
| Severity | LOW |
|---|---|
| Evidence Tier | Moderate |
| Interaction Type | SYNERGISTIC |
| Mechanism | PHARMACODYNAMIC |
| Last Reviewed | 2026-02-15 |
Summary
Sulforaphane increases PXR expression which clears plasticizers from VDR, improving D3 binding. Consider taking sulforaphane with D3 for enhanced VDR activation
API Reference
GET https://api.truthstack.co/v1/check?c1=Sulforaphane&c2=Vitamin%20D
Open, unauthenticated. Returns JSON. Developer documentation
Related Interactions
What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.