Lisinopril and Magnesium
Supplement–drug interaction evidence from the TruthStack database.
| Severity | HIGH |
|---|---|
| Evidence Tier | Moderate |
| Interaction Type | SAFETY CONCERN |
| Mechanism | PHARMACODYNAMIC |
| Last Reviewed | 2026-02-24 |
Source Verification
Attestation METHODOLOGY_ATTESTED
Corpus manifest 26b2d684...
Last reviewed 2026-02-24
Primary source 27402061
Live attestation Query API — returns signed DAA ID per request
Data license CC BY 4.0
Summary
Magnesium has independent vasodilatory and mild antihypertensive effects. Combined with ACE inhibitors, additive blood pressure lowering possible. ACE inhibitors may promote magnesium retention. FAERS: 11,533 reports. Monitor blood pressure. Generally well-tolerated at standard supplemental doses.
API Reference
GET https://api.truthstack.co/v1/check?c1=lisinopril&c2=magnesium
Open, unauthenticated. Returns JSON. Developer documentation
Sources
Primary: 27402061
Related Interactions
What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.