Grapefruit Extract and Oxycodone

Supplement–drug interaction evidence from the TruthStack database.

SeverityHIGH
Evidence TierModerate
Interaction TypePHARMACODYNAMIC RISK
MechanismPHARMACOKINETIC
Last Reviewed2026-02-15

Summary

Grapefruit inhibits CYP3A4. Oxycodone levels increase with risk of excessive sedation and respiratory depression. Discuss with your prescriber or pharmacist.

API Reference

GET https://api.truthstack.co/v1/check?c1=grapefruit%20extract&c2=oxycodone

Open, unauthenticated. Returns JSON. Developer documentation

Related Interactions

Cyclosporine + Grapefruit Extract Grapefruit Extract + Simvastatin Grapefruit Extract + Tacrolimus Kava + Oxycodone Cbd + Oxycodone Goldenseal + Oxycodone Alprazolam + Grapefruit Extract Amlodipine + Grapefruit Extract
What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.