Glycine and L-Theanine
Supplement–drug interaction evidence from the TruthStack database.
| Severity | LOW |
|---|---|
| Evidence Tier | Moderate |
| Interaction Type | COMPLEMENTARY |
| Mechanism | PHARMACODYNAMIC |
| Last Reviewed | 2026-02-16 |
Summary
Both promote relaxation: L-theanine via alpha wave activity, glycine via NMDA receptor and body temperature reduction. Overlapping calming effects when stacked with other sedative compounds.
API Reference
GET https://api.truthstack.co/v1/check?c1=Glycine&c2=L-Theanine
Open, unauthenticated. Returns JSON. Developer documentation
Related Interactions
What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.