Fluoxetine and Valerian
Supplement–drug interaction evidence from the TruthStack database.
| Severity | MODERATE |
|---|---|
| Evidence Tier | Limited |
| Interaction Type | SAFETY CONCERN |
| Mechanism | PHARMACODYNAMIC |
| Last Reviewed | 2026-02-10 |
Summary
Monitor closely. 19 serious adverse events reported with this combination in FDA FAERS. Pharmacovigilance signal, not proof of causation. Discuss with prescriber.
What We Don't Know
This interaction has limited evidence. Key gaps may include: direct clinical trial data for this specific combination, dose-response relationships, and long-term outcome data. Absence of evidence is not evidence of absence.
API Reference
GET https://api.truthstack.co/v1/check?c1=fluoxetine&c2=valerian
Open, unauthenticated. Returns JSON. Developer documentation
Related Interactions
What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.