Caffeine and Yohimbine
Supplement–drug interaction evidence from the TruthStack database.
| Severity | MODERATE |
|---|---|
| Evidence Tier | Moderate |
| Interaction Type | PHARMACODYNAMIC RISK |
| Mechanism | CARDIOVASCULAR |
| Last Reviewed | 2026-02-16 |
Summary
Both yohimbine and caffeine are stimulants with cardiovascular effects. Combined use may increase heart rate and blood pressure. Literature flags additive sympathomimetic effects.
API Reference
GET https://api.truthstack.co/v1/check?c1=Caffeine&c2=Yohimbine
Open, unauthenticated. Returns JSON. Developer documentation
Related Interactions
What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.