Apixaban and Vitamin E
Supplement–drug interaction evidence from the TruthStack database.
| Severity | MODERATE |
|---|---|
| Evidence Tier | Moderate |
| Interaction Type | BLEEDING RISK |
| Mechanism | PHARMACODYNAMIC |
| Last Reviewed | 2026-02-24 |
Source Verification
Attestation METHODOLOGY_ATTESTED
Corpus manifest 26b2d684...
Last reviewed 2026-02-24
Primary source 15998891
Live attestation Query API — returns signed DAA ID per request
Data license CC BY 4.0
Summary
Antiplatelet properties at >400 IU/day. HOPE-TOO trial documented increased hemorrhagic events.
API Reference
GET https://api.truthstack.co/v1/check?c1=Apixaban&c2=Vitamin%20E
Open, unauthenticated. Returns JSON. Developer documentation
Sources
Primary: 15998891
Related Interactions
What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.