Acetaminophen and Tirzepatide

Supplement–drug interaction evidence from the TruthStack database.

SeverityMODERATE
Evidence TierModerate
Interaction TypeABSORPTION INTERFERENCE
MechanismABSORPTION
Last Reviewed2026-02-16

Summary

GLP-1 agonists delay gastric emptying, reducing acetaminophen absorption rate. Literature documents delayed Cmax by 1-3 hours. Clinical significance varies. Discuss with your prescriber or pharmacist.

API Reference

GET https://api.truthstack.co/v1/check?c1=Acetaminophen&c2=Tirzepatide

Open, unauthenticated. Returns JSON. Developer documentation

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What this page is and is not. TruthStack is an informational reference database that describes published pharmacological findings. It does not provide medical advice, diagnosis, or treatment recommendations. The information on this page reflects flags in our database and should not replace consultation with a qualified healthcare provider. Always discuss supplement-drug combinations with your prescriber or pharmacist.